Mitochondria and Lysosomes: Discovering Bonds
نویسندگان
چکیده
منابع مشابه
Mitochondria and Lysosomes: Discovering Bonds
In the last decade, the traditional view of lysosomes has been challenged by the recognition that lysosomes are not only degradative organelles, but also metabolic sensors that play a key role in the regulation of metabolism and cell growth. Similarly, mitochondria are now seen as crucial metabolic hubs dictating cell fate decisions, not just ATP-producing machines. Importantly, these functions...
متن کاملCrosstalk between Lysosomes and Mitochondria in Parkinson's Disease
Parkinson's disease (PD) is the most common motor neurodegenerative disorder. In most cases the cause of the disease is unknown, while in about 10% of subjects, it is associated with mutations in a number of different genes. Several different mutations in 15 genes have been identified as causing familial forms of the disease, while many others have been identified as risk factors. A striking nu...
متن کاملTwo-photon fluorescence probes for imaging of mitochondria and lysosomes.
Novel biocompatible cyanines show not only a very large two-photon cross-section of up to 5130 GM at 910 nm in aqueous medium for high-contrast and -brightness two-photon fluorescence live cell imaging but also highly selective subcellular localization properties including localization of mitochondria and lysosomes.
متن کاملA Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes
Mitochondrial respiration relies on electron transport, an essential yet dangerous process in that it leads to the generation of reactive oxygen species (ROS). ROS can be neutralized within the mitochondria through enzymatic activity, yet the mechanism for steady-state removal of oxidized mitochondrial protein complexes and lipids is not well understood. We have previously characterized vesicul...
متن کاملTestosterone - Mediated Sexual Dimorphism of the Rodent Heart Ventricular Lysosomes , Mitochondria , and Cell Growth are Modulated
The ventricular myocardium was studied in A/J mice and in Sprague-Dawley rats. In male mice, the ventricles were slightly larger and the specific activities of the lysosomal hydrolases, /8-glucuronidase, hexosaminidase, /?-galactosidase, and arylsulphatase, and the inner mitochondrial enzyme cytochrome c oxidase were substantially higher than in female mice. Orchiectomy abolished this sex diffe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2017
ISSN: 2296-634X
DOI: 10.3389/fcell.2017.00106